Calpain-cleaved Type 1 Inositol 1,4,5-Trisphosphate Receptor (InsP(3)R1) Has InsP(3)-independent Gating and Disrupts Intracellular Ca(2+) Homeostasis

The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a ubiquitous intracellular Ca(2+) release channel that is vital to intracellular Ca(2+) signaling. InsP(3)R1 is a proteolytic target of calpain, which cleaves the channel to form a 95-kDa carboxyl-terminal fragment that includes the tra...

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Bibliographic Details
Main Authors: Kopil, Catherine M., Vais, Horia, Cheung, King-Ho, Siebert, Adam P., Mak, Don-On Daniel, Foskett, J. Kevin, Neumar, Robert W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195633/
https://ncbi.nlm.nih.gov/pubmed/21859719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254177
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