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Analyzing and Quantifying the Gain-of-Function Enhancement of IP(3) Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins
Familial Alzheimer’s disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) Ca(2+) release channels resulting in enhanced IP(3)R channel gating in an amyloid beta (Aβ) production-independent manner. This gain-of-function enhancement of IP(3...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4595473/ https://ncbi.nlm.nih.gov/pubmed/26439382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004529 |
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