Загрузка...

Analyzing and Quantifying the Gain-of-Function Enhancement of IP(3) Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins

Familial Alzheimer’s disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) Ca(2+) release channels resulting in enhanced IP(3)R channel gating in an amyloid beta (Aβ) production-independent manner. This gain-of-function enhancement of IP(3...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :PLoS Comput Biol
Главные авторы: Mak, Don-On Daniel, Cheung, King-Ho, Toglia, Patrick, Foskett, J. Kevin, Ullah, Ghanim
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595473/
https://ncbi.nlm.nih.gov/pubmed/26439382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004529
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!