Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo

Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-lowering effects by inhibiting hepatic gluconeogenesis. However, the primary molecular mechanism of this biguanide remains unresolved, though it has been suggested to act, at least partially, by mitocho...

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Veröffentlicht in:Nat Med
Hauptverfasser: Madiraju, Anila K., Qiu, Yang, Perry, Rachel J., Rahimi, Yasmeen, Zhang, Xian-Man, Zhang, Dongyan, Camporez, João-Paulo G., Cline, Gary W., Butrico, Gina M., Kemp, Bruce E., Casals, Gregori, Steinberg, Gregory R., Vatner, Daniel F., Petersen, Kitt Falk, Shulman, Gerald I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129196/
https://ncbi.nlm.nih.gov/pubmed/30038219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0125-4
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