Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

OBJECTIVE: Both glucose and triglyceride production are increased in type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). For decades, the leading hypothesis to explain these paradoxical observations has been selective hepatic insulin resistance wherein insulin drives de novo lipogenesis (D...

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Detalhes bibliográficos
Publicado no:Diabetes Care
Main Authors: ter Horst, Kasper W., Vatner, Daniel F., Zhang, Dongyan, Cline, Gary W., Ackermans, Mariette T., Nederveen, Aart J., Verheij, Joanne, Demirkiran, Ahmet, van Wagensveld, Bart A., Dallinga-Thie, Geesje M., Nieuwdorp, Max, Romijn, Johannes A., Shulman, Gerald I., Serlie, Mireille J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2021
Assuntos:
Pathophysiology/Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818337/
https://ncbi.nlm.nih.gov/pubmed/33293347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc20-1644
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