Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function

por Stitzel, Michael L., Kycia, Ina, Kursawe, Romy, Ucar, Duygu
Publicado en Curr Diab Rep (2015)

Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts

por Lawlor, Nathan, Youn, Ahrim, Kursawe, Romy, Ucar, Duygu, Stitzel, Michael L.
Publicado en Sci Rep (2017)

The Association Between Hepatic Fat Content and Liver Injury in Obese Children and Adolescents: Effects of ethnicity, insulin resistance, and common gene variants

por Santoro, Nicola, Feldstein, Ariel E., Enoksson, Erik, Pierpont, Bridget, Kursawe, Romy, Kim, Grace, Caprio, Sonia
Publicado 2013

Circulating Levels of FGF-21 in Obese Youth: Associations With Liver Fat Content and Markers of Liver Damage

por Giannini, Cosimo, Feldstein, Ariel E., Santoro, Nicola, Kim, Grace, Kursawe, Romy, Pierpont, Bridget, Caprio, Sonia
Publicado 2013

Downregulation of ADIPOQ and PPARγ2 Gene-Expression in Subcutaneous Adipose Tissue of Obese Adolescents With Hepatic Steatosis

por Kursawe, Romy, Narayan, Deepak, Cali, Anna M.G., Shaw, Melissa, Pierpont, Bridget, Shulman, Gerald I., Caprio, Sonia
Publicado 2010

Oxidized Fatty Acids: A Potential Pathogenic Link Between Fatty Liver and Type 2 Diabetes in Obese Adolescents?

por Santoro, Nicola, Caprio, Sonia, Giannini, Cosimo, Kim, Grace, Kursawe, Romy, Pierpont, Bridget, Shaw, Melissa M., Feldstein, Ariel E.
Publicado 2014

Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets

por Khetan, Shubham, Kursawe, Romy, Youn, Ahrim, Lawlor, Nathan, Jillette, Alexandria, Marquez, Eladio J., Ucar, Duygu, Stitzel, Michael L.
Publicado en Diabetes (2018)

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

por Lawlor, Nathan, George, Joshy, Bolisetty, Mohan, Kursawe, Romy, Sun, Lili, Sivakamasundari, V., Kycia, Ina, Robson, Paul, Stitzel, Michael L.
Publicado en Genome Res (2017)

Caspase-12, but not caspase-11, inhibits obesity and insulin resistance

por Skeldon, Alexander M., Morizot, Alexandre, Douglas, Todd, Santoro, Nicola, Kursawe, Romy, Kozlitina, Julia, Caprio, Sonia, Mehal, Wajahat Z., Saleh, Maya
Publicado en J Immunol (2015)

The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity

por Cropano, Catrina, Santoro, Nicola, Groop, Leif, Dalla Man, Chiara, Cobelli, Claudio, Galderisi, Alfonso, Kursawe, Romy, Pierpont, Bridget, Goffredo, Martina, Caprio, Sonia
Publicado en Diabetes Care (2017)

Longitudinal Effects of MRI-Measured Hepatic Steatosis on Biomarkers of Glucose Homeostasis and Hepatic Apoptosis in Obese Youth

por Kim, Grace, Giannini, Cosimo, Pierpont, Bridget, Feldstein, Ariel E., Santoro, Nicola, Kursawe, Romy, Shaw, Melissa, Duran, Elvira, Goldberg, Rachel, Dziura, James, Caprio, Sonia
Publicado 2013

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Re...

por Kursawe, Romy, Caprio, Sonia, Giannini, Cosimo, Narayan, Deepak, Lin, Aiping, D’Adamo, Ebe, Shaw, Melissa, Pierpont, Bridget, Cushman, Samuel W., Shulman, Gerald I.
Publicado 2013

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

por Nouws, Jessica, Fitch, Mark, Mata, Mariana, Santoro, Nicola, Galuppo, Brittany, Kursawe, Romy, Narayan, Deepak, Vash-Margita, Alla, Pierpont, Bridget, Shulman, Gerald I., Hellerstein, Marc, Caprio, Sonia
Publicado en Diabetes (2019)

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

por Kursawe, Romy, Dixit, Vishwa D., Scherer, Philipp E., Santoro, Nicola, Narayan, Deepak, Gordillo, Ruth, Giannini, Cosimo, Lopez, Ximena, Pierpont, Bridget, Nouws, Jessica, Shulman, Gerald I., Caprio, Sonia
Publicado en Diabetes (2016)

Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial

por Savoye, Mary, Caprio, Sonia, Dziura, James, Camp, Anne, Germain, Greg, Summers, Craig, Li, Fangyong, Shaw, Melissa, Nowicka, Paulina, Kursawe, Romy, DePourcq, Fredrick, Kim, Grace, Tamborlane, William V.
Publicado 2014

Blunted Suppression of Acyl-Ghrelin in Response to Fructose Ingestion in Obese Adolescents: the Role of Insulin Resistance

por Van Name, Michelle, Giannini, Cosimo, Santoro, Nicola, Jastreboff, Ania, Kubat, Jessica, Li, Fangyong, Kursawe, Romy, Savoye, Mary, Duran, Elvira, Dziura, James, Sinha, Rajita, Sherwin, Robert, Cline, Gary, Caprio, Sonia
Publicado en Obesity (Silver Spring) (2015)

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

por Kursawe, Romy, Eszlinger, Markus, Narayan, Deepak, Liu, Teresa, Bazuine, Merlijn, Cali, Anna M.G., D'Adamo, Ebe, Shaw, Melissa, Pierpont, Bridget, Shulman, Gerald I., Cushman, Samuel W., Sherman, Arthur, Caprio, Sonia
Publicado 2010

A Variant in the Glucokinase Regulatory Protein (GCKR) Gene is Associated with Fatty Liver in Obese Children and Adolescents

por Santoro, Nicola, Zhang, Clarence K., Zhao, Hongyu, Pakstis, Andrew J, Kim, Grace, Kursawe, Romy, Dykas, Daniel J., Bale, Allen E., Giannini, Cosimo, Pierpont, Bridget, Shaw, Melissa M., Leif, Groop, Caprio, Sonia
Publicado 2011

Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

por Chutkow, William A., Birkenfeld, Andreas L., Brown, Jonathan D., Lee, Hui-Young, Frederick, David W., Yoshioka, Jun, Patwari, Parth, Kursawe, Romy, Cushman, Samuel W., Plutzky, Jorge, Shulman, Gerald I., Samuel, Varman T., Lee, Richard T.
Publicado 2010

Glucose Dysregulation and Hepatic Steatosis in Obese Adolescents: Is there a link?

por Cali, Anna MG, De Oliveira, Ana Mayra, Kim, Hyeonjin, Chen, Shu, Reyes-Mugica, Miguel, Escalera, Sandra, Dziura, James, Taksali, Sara E., Kursawe, Romy, Shaw, Melissa, Savoye, Mary, Pierpont, Bridget, Constable, R Todd, Caprio, Sonia
Publicado 2009