The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity

OBJECTIVE: In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146 risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) in obese adolescents. RESEARCH DESIGN AND METHODS: The rs7903146 variant in the TCF7L2 gene was genotyped in a multiet...

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Detalhes bibliográficos
Publicado no:Diabetes Care
Main Authors: Cropano, Catrina, Santoro, Nicola, Groop, Leif, Dalla Man, Chiara, Cobelli, Claudio, Galderisi, Alfonso, Kursawe, Romy, Pierpont, Bridget, Goffredo, Martina, Caprio, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Pathophysiology/Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521977/
https://ncbi.nlm.nih.gov/pubmed/28611053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc17-0290
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