A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth

OBJECTIVE: The risk genotype for the common variant rs7903146 of the transcription factor 7-like-2 (TCF7L2) gene has been found to affect the incretin response in healthy and obese adults; however, whether a similar functional defect is also present in obese adolescents remains unexplored. Herein, w...

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Vydáno v:Diabetes Care
Hlavní autoři: Galderisi, Alfonso, Tricò, Domenico, Pierpont, Bridget, Shabanova, Veronika, Samuels, Stephanie, Dalla Man, Chiara, Galuppo, Brittany, Santoro, Nicola, Caprio, Sonia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2020
Témata:
Pathophysiology/Complications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510033/
https://ncbi.nlm.nih.gov/pubmed/32788279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc20-0445
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