Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

OBJECTIVE: Thioredoxin interacting protein (Txnip), a regulator of cellular oxidative stress, is induced by hyperglycemia and inhibits glucose uptake into fat and muscle, suggesting a role for Txnip in type 2 diabetes pathogenesis. Here, we tested the hypothesis that Txnip-null (knockout) mice are p...

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Detalhes bibliográficos
Main Authors: Chutkow, William A., Birkenfeld, Andreas L., Brown, Jonathan D., Lee, Hui-Young, Frederick, David W., Yoshioka, Jun, Patwari, Parth, Kursawe, Romy, Cushman, Samuel W., Plutzky, Jorge, Shulman, Gerald I., Samuel, Varman T., Lee, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874703/
https://ncbi.nlm.nih.gov/pubmed/20299477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1212
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