Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice

Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic insulin resistance. Here, we performed comprehensi...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Abulizi, Abudukadier, Vatner, Daniel F., Ye, Zhang, Wang, Yongliang, Camporez, Joao-Paulo, Zhang, Dongyan, Kahn, Mario, Lyu, Kun, Sirwi, Alaa, Cline, Gary W., Hussain, M. Mahmood, Aspichueta, Patricia, Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707176/
https://ncbi.nlm.nih.gov/pubmed/32907986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000586
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