Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats

The steroid receptor coactivator 1 (SRC1) regulates key metabolic pathways, including glucose homeostasis. SRC1(−/−) mice have decreased hepatic expression of gluconeogenic enzymes and a reduction in the rate of endogenous glucose production (EGP). We sought to determine whether decreasing hepatic a...

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Main Authors: Cantley, Jennifer L., Vatner, Daniel F., Galbo, Thomas, Madiraju, Anila, Petersen, Max, Perry, Rachel J., Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Gattu, Arijeet K., Stacy, Mitchel R., Dione, Donald P., Sinusas, Albert J., Ragolia, Louis, Hall, Christopher E., Manchem, Vara Prasad, Bhanot, Sanjay, Bogan, Jonathan S., Samuel, Varman T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216948/
https://ncbi.nlm.nih.gov/pubmed/25159329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00148.2014
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