Role of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats

Genome-wide array studies have associated the patatin-like phospholipase domain-containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis. However, it is unclear whether PNPLA3 functions as a lipase or a lipogenic enzyme and whether PNPLA3 is involved in the pathogenesis of hepatic insulin res...

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Detalhes bibliográficos
Main Authors: Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L, Majumdar, Sachin K, Guebre-Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F, Fat, Ioana, Kahn, Mario, Erion, Derek M, Zhang, Xian-Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S, Petersen, Kitt F, Cline, Gary W, Samuel, Varman T, Shulman, Gerald I
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2013
Assuntos:
Steatohepatitis/Metabolic Liver Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597437/
https://ncbi.nlm.nih.gov/pubmed/23175050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26170
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