Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Pesta, Dominik H., Perry, Rachel J., Guebre-Egziabher, Fitsum, Zhang, Dongyan, Jurczak, Michael, Fischer-Rosinsky, Antje, Daniels, Martin A., Willmes, Diana M., Bhanot, Sanjay, Bornstein, Stefan R., Knauf, Felix, Samuel, Varman T., Shulman, Gerald I., Birkenfeld, Andreas L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712334/
https://ncbi.nlm.nih.gov/pubmed/26647160
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