Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-...

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Foilsithe in:Aging (Albany NY)
Main Authors: Pesta, Dominik H., Perry, Rachel J., Guebre-Egziabher, Fitsum, Zhang, Dongyan, Jurczak, Michael, Fischer-Rosinsky, Antje, Daniels, Martin A., Willmes, Diana M., Bhanot, Sanjay, Bornstein, Stefan R., Knauf, Felix, Samuel, Varman T., Shulman, Gerald I., Birkenfeld, Andreas L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2015
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712334/
https://ncbi.nlm.nih.gov/pubmed/26647160
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