Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Although mutations in the Wnt/β-catenin signaling pathway are linked with the metabolic syndrome and type 2 diabetes in humans, the mechanism is unclear. High-fat-fed male C57BL/6 mice were treated for 4 wk with a 2′-O-methoxyethyl chimeric antisense oligonucleotide (ASO) to decrease hepatic and adi...

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Vydáno v:FASEB J
Hlavní autoři: Popov, Violeta B., Jornayvaz, Francois R., Akgul, Emin O., Kanda, Shoichi, Jurczak, Michael J., Zhang, Dongyan, Abudukadier, Abulizi, Majumdar, Sachin K., Guigni, Blas, Petersen, Kitt Falk, Manchem, Vara Prasad, Bhanot, Sanjay, Shulman, Gerald I., Samuel, Varman T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750414/
https://ncbi.nlm.nih.gov/pubmed/26644352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271999
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