Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Although mutations in the Wnt/β-catenin signaling pathway are linked with the metabolic syndrome and type 2 diabetes in humans, the mechanism is unclear. High-fat-fed male C57BL/6 mice were treated for 4 wk with a 2′-O-methoxyethyl chimeric antisense oligonucleotide (ASO) to decrease hepatic and adi...

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Библиографические подробности
Опубликовано в: :FASEB J
Главные авторы: Popov, Violeta B., Jornayvaz, Francois R., Akgul, Emin O., Kanda, Shoichi, Jurczak, Michael J., Zhang, Dongyan, Abudukadier, Abulizi, Majumdar, Sachin K., Guigni, Blas, Petersen, Kitt Falk, Manchem, Vara Prasad, Bhanot, Sanjay, Shulman, Gerald I., Samuel, Varman T.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2016
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750414/
https://ncbi.nlm.nih.gov/pubmed/26644352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271999
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