Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Although mutations in the Wnt/β-catenin signaling pathway are linked with the metabolic syndrome and type 2 diabetes in humans, the mechanism is unclear. High-fat-fed male C57BL/6 mice were treated for 4 wk with a 2′-O-methoxyethyl chimeric antisense oligonucleotide (ASO) to decrease hepatic and adi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Popov, Violeta B., Jornayvaz, Francois R., Akgul, Emin O., Kanda, Shoichi, Jurczak, Michael J., Zhang, Dongyan, Abudukadier, Abulizi, Majumdar, Sachin K., Guigni, Blas, Petersen, Kitt Falk, Manchem, Vara Prasad, Bhanot, Sanjay, Shulman, Gerald I., Samuel, Varman T.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750414/
https://ncbi.nlm.nih.gov/pubmed/26644352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271999
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados