Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Although mutations in the Wnt/β-catenin signaling pathway are linked with the metabolic syndrome and type 2 diabetes in humans, the mechanism is unclear. High-fat-fed male C57BL/6 mice were treated for 4 wk with a 2′-O-methoxyethyl chimeric antisense oligonucleotide (ASO) to decrease hepatic and adi...

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Bibliografski detalji
Izdano u:FASEB J
Glavni autori: Popov, Violeta B., Jornayvaz, Francois R., Akgul, Emin O., Kanda, Shoichi, Jurczak, Michael J., Zhang, Dongyan, Abudukadier, Abulizi, Majumdar, Sachin K., Guigni, Blas, Petersen, Kitt Falk, Manchem, Vara Prasad, Bhanot, Sanjay, Shulman, Gerald I., Samuel, Varman T.
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2016
Teme:
Research Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750414/
https://ncbi.nlm.nih.gov/pubmed/26644352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271999
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