Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

Por Wyvekens, Nicolas, Topkar, Ved V., Khayter, Cyd, Joung, J. Keith, Tsai, Shengdar Q.
Publicado no Hum Gene Ther (2015)

FLASH Assembly of TALENs Enables High-Throughput Genome Editing

Por Reyon, Deepak, Tsai, Shengdar Q., Khayter, Cyd, Foden, Jennifer A., Sander, Jeffry D., Joung, J. Keith
Publicado em 2012

High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets

Por Kleinstiver, Benjamin P., Pattanayak, Vikram, Prew, Michelle S., Tsai, Shengdar Q., Nguyen, Nhu, Zheng, Zongli, Joung, J. Keith
Publicado no Nature (2016)

Correction of the Crb1(rd8) Allele and Retinal Phenotype in C57BL/6N Mice Via TALEN-Mediated Homology-Directed Repair

Por Low, Benjamin E., Krebs, Mark P., Joung, J. Keith, Tsai, Shengdar Q., Nishina, Patsy M., Wiles, Michael V.
Publicado em 2014

Broadening Staphylococcus aureus Cas9 Targeting Range by Modifying PAM Recognition

Por Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Nguyen, Nhu T., Topkar, Ved V., Zheng, Zongli, Joung, J. Keith
Publicado no Nat Biotechnol (2015)

Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-based Automatable Solid-phase High-throughput (FLASH) Assembly

Por Reyon, Deepak, Maeder, Morgan L., Khayter, Cyd, Tsai, Shengdar Q., Foley, Jonathan E., Sander, Jeffry D., Joung, J. Keith
Publicado em 2013

Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity

Por Guilinger, John P., Pattanayak, Vikram, Reyon, Deepak, Tsai, Shengdar Q., Sander, Jeffry D., Joung, J. Keith, Liu, David R.
Publicado em 2014

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

Por Tsai, Shengdar Q., Wyvekens, Nicolas, Khayter, Cyd, Foden, Jennifer A., Thapar, Vishal, Reyon, Deepak, Goodwin, Mathew J., Aryee, Martin J., Joung, J. Keith
Publicado em 2014

Differences in X-Chromosome Transcriptional Activity and Cholesterol Metabolism between Placentae from Swine Breeds from Asian and Western Origins

Por Bischoff, Steve R., Tsai, Shengdar Q., Hardison, Nicholas E., Motsinger-Reif, Alison A., Freking, Bradley A., Nonneman, Dan J., Rohrer, Gary A., Piedrahita, Jorge A.
Publicado em 2013

Efficient In Vivo Genome Editing Using RNA-Guided Nucleases

Por Hwang, Woong Y., Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L., Tsai, Shengdar Q., Sander, Jeffry D., Peterson, Randall T., Yeh, J.-R. Joanna, Joung, J. Keith
Publicado em 2013

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

Por Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y., Tsai, Shengdar Q., Patel, Samir, Khayter, Cyd, Joung, J. Keith, Sander, Jeffry D., Peterson, Randall T., Yeh, Jing-Ruey Joanna
Publicado em 2012

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

Por Kleinstiver, Benjamin P., Tsai, Shengdar Q., Prew, Michelle S., Nguyen, Nhu T., Welch, Moira M., Lopez, Jose M., McCaw, Zachary R., Aryee, Martin J., Joung, J. Keith
Publicado no Nat Biotechnol (2016)

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity

Por Hubbard, Basil P., Badran, Ahmed H., Zuris, John A., Guilinger, John P., Davis, Kevin M., Chen, Liwei, Tsai, Shengdar Q., Sander, Jeffry D., Joung, J. Keith, Liu, David R.
Publicado no Nat Methods (2015)

GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Por Tsai, Shengdar Q., Zheng, Zongli, Nguyen, Nhu T., Liebers, Matthew, Topkar, Ved V., Thapar, Vishal, Wyvekens, Nicolas, Khayter, Cyd, Iafrate, A. John, Le, Long P., Aryee, Martin J., Joung, J. Keith
Publicado no Nat Biotechnol (2014)

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Por Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Topkar, Ved, Nguyen, Nhu T., Zheng, Zongli, Gonzales, Andrew P.W., Li, Zhuyun, Peterson, Randall T., Yeh, Jing-Ruey Joanna, Aryee, Martin J., Joung, J. Keith
Publicado no Nature (2015)

Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors

Por Pauli, Andrea, Norris, Megan L., Valen, Eivind, Chew, Guo-Liang, Gagnon, James A., Zimmerman, Steven, Mitchell, Andrew, Ma, Jiao, Dubrulle, Julien, Reyon, Deepak, Tsai, Shengdar Q., Joung, J. Keith, Saghatelian, Alan, Schier, Alexander F.
Publicado em 2014

Targeted DNA Demethylation and Endogenous Gene Activation Using Programmable TALE-TET1 Fusions

Por Maeder, Morgan L, Angstman, James F, Richardson, Marcy E, Linder, Samantha J, Cascio, Vincent M, Tsai, Shengdar Q, Ho, Quan H, Sander, Jeffry D, Reyon, Deepak, Bernstein, Bradley E, Costello, Joseph F, Wilkinson, Miles F, Joung, J Keith
Publicado em 2013

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

Por Liao, Jing, Karnik, Rahul, Gu, Hongcang, Ziller, Michael J., Clement, Kendell, Tsankov, Alexander M., Akopian, Veronika, Gifford, Casey A., Donaghey, Julie, Galonska, Christina, Pop, Ramona, Reyon, Deepak, Tsai, Shengdar Q., Mallard, William, Joung, J. Keith, Rinn, John L., Gnirke, Andreas, Meissner, Alexander
Publicado no Nat Genet (2015)

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

Por Hill, Sarah J., Rolland, Thomas, Adelmant, Guillaume, Xia, Xianfang, Owen, Matthew S., Dricot, Amélie, Zack, Travis I., Sahni, Nidhi, Jacob, Yves, Hao, Tong, McKinney, Kristine M., Clark, Allison P., Reyon, Deepak, Tsai, Shengdar Q., Joung, J. Keith, Beroukhim, Rameen, Marto, Jarrod A., Vidal, Marc, Gaudet, Suzanne, Hill, David E., Livingston, David M.
Publicado em 2014