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GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
CRISPR RNA-guided nucleases (RGNs) are widely used genome-editing reagents, but methods to delineate their genome-wide off-target cleavage activities have been lacking. Here we describe an approach for global detection of DNA double-stranded breaks (DSBs) introduced by RGNs and potentially other nuc...
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| 出版年: | Nat Biotechnol |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4320685/ https://ncbi.nlm.nih.gov/pubmed/25513782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3117 |
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