Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Although CRISPR-Cas9 nucleases are widely used for genome editing(1, 2), the range of sequences that Cas9 can recognize is constrained by the need for a specific protospacer adjacent motif (PAM)(3–6). As a result, it can often be difficult to target double-stranded breaks (DSBs) with the precision t...

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Publicado no:Nature
Main Authors: Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Topkar, Ved, Nguyen, Nhu T., Zheng, Zongli, Gonzales, Andrew P.W., Li, Zhuyun, Peterson, Randall T., Yeh, Jing-Ruey Joanna, Aryee, Martin J., Joung, J. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540238/
https://ncbi.nlm.nih.gov/pubmed/26098369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14592
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