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Broadening Staphylococcus aureus Cas9 Targeting Range by Modifying PAM Recognition
CRISPR-Cas9 nucleases are primarily guided by RNA-DNA interactions but also require Cas9-mediated recognition of a protospacer adjacent motif (PAM). While potentially advantageous for specificity, extended PAM sequences limit the targeting range of Cas9 orthologues for genome editing. One possible s...
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| Publicado no: | Nat Biotechnol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689141/ https://ncbi.nlm.nih.gov/pubmed/26524662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3404 |
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