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Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

CRISPR-Cas9 RNA-guided nucleases are a transformative technology for biology, genetics, and medicine due to the simplicity with which they can be programmed to cleave specific DNA target sites in living cells and organisms. However, to translate these powerful molecular tools into safe, effective cl...

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書目詳細資料
發表在:Nat Rev Genet
Main Authors: Tsai, Shengdar Q., Joung, J. Keith
格式: Artigo
語言:Inglês
出版: 2016
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225572/
https://ncbi.nlm.nih.gov/pubmed/27087594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2016.28
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