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Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

CRISPR-Cas9 RNA-guided nucleases are a transformative technology for biology, genetics, and medicine due to the simplicity with which they can be programmed to cleave specific DNA target sites in living cells and organisms. However, to translate these powerful molecular tools into safe, effective cl...

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Bibliographic Details
Published in:Nat Rev Genet
Main Authors: Tsai, Shengdar Q., Joung, J. Keith
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225572/
https://ncbi.nlm.nih.gov/pubmed/27087594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2016.28
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