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Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases
CRISPR-Cas9 RNA-guided nucleases are a transformative technology for biology, genetics, and medicine due to the simplicity with which they can be programmed to cleave specific DNA target sites in living cells and organisms. However, to translate these powerful molecular tools into safe, effective cl...
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| 出版年: | Nat Rev Genet |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7225572/ https://ncbi.nlm.nih.gov/pubmed/27087594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2016.28 |
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