Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

Monomeric clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated 9 (Cas9) nucleases have been widely adopted for simple and robust targeted genome editing but also have the potential to induce high-frequency off-target mutations. In principle, two orthogonal strategies...

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Bibliografiske detaljer
Udgivet i:Hum Gene Ther
Main Authors: Wyvekens, Nicolas, Topkar, Ved V., Khayter, Cyd, Joung, J. Keith, Tsai, Shengdar Q.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509490/
https://ncbi.nlm.nih.gov/pubmed/26068112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.084
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