Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

Transcription activator-like effector nucleases (TALENs) are powerful new research tools that enable targeted gene disruption in a wide variety of model organisms. Recent work has shown that TALENs can induce mutations in endogenous zebrafish genes, but to date only four genes have been altered, and...

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Hlavní autoři: Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y., Tsai, Shengdar Q., Patel, Samir, Khayter, Cyd, Joung, J. Keith, Sander, Jeffry D., Peterson, Randall T., Yeh, Jing-Ruey Joanna
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439908/
https://ncbi.nlm.nih.gov/pubmed/22684503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks518
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