Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry()

Por Hagen, Susan E., Liu, Kun, Jin, Yafei, Piersimoni, Lolita, Andrews, Philip C., Showalter, Hollis D.
Publicado no Org Biomol Chem (2018)

Design, Synthesis, and Biological Activity of 5′-Phenyl-1,2,5,6-tetrahydro-3,3′-bipyridine Analogues as Potential Antagonists of Nicotinic Acetylcholine Receptors

Por Jin, Yafei, Huang, Xiaoqin, Papke, Roger L., Jutkiewicz, Emily M., Showalter, Hollis D., Zhan, Chang-Guo
Publicado no Bioorg Med Chem Lett (2017)

Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C

Por Carpenter, Colleen, Sorenson, Roderick J., Jin, Yafei, Klossowski, Szymon, Cierpicki, Tomascz, Gnegy, Margaret, Showalter, Hollis D.
Publicado no Bioorg Med Chem (2016)

Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response

Por Perry, Jeffrey W., Ahmed, Mohammad, Chang, Kyeong-Ok, Donato, Nicholas J., Showalter, Hollis D., Wobus, Christiane E.
Publicado em 2012

RecO and RecR Are Necessary for RecA Loading in Response to DNA Damage and Replication Fork Stress

Por Lenhart, Justin S., Brandes, Eileen R., Schroeder, Jeremy W., Sorenson, Roderick J., Showalter, Hollis D., Simmons, Lyle A.
Publicado em 2014

Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine...

Por Chen, Yi-Chen, Brooks, Allen F., Goodenough-Lashua, DeeAnne M., Kittendorf, Jeffrey D., Showalter, Hollis D., Garcia, George A.
Publicado em 2011

Small Molecule Deubiquitinase Inhibitors Promote Macrophage Anti-Infective Capacity

Por Charbonneau, Marie-Eve, Gonzalez-Hernandez, Marta J., Showalter, Hollis D., Donato, Nicholas J., Wobus, Christiane E., O’Riordan, Mary X. D.
Publicado em 2014

A Small Molecule Deubiquitinase Inhibitor Increases Localization of Inducible Nitric Oxide Synthase to the Macrophage Phagosome and Enhances Bacterial Killing

Por Burkholder, Kristin M., Perry, Jeffrey W., Wobus, Christiane E., Donato, Nicholas J., Showalter, Hollis D., Kapuria, Vaibhav, O'Riordan, Mary X. D.
Publicado em 2011

Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

Por Carpenter, Colleen, Zestos, Alexander G, Altshuler, Rachel, Sorenson, Roderick J, Guptaroy, Bipasha, Showalter, Hollis D, Kennedy, Robert T, Jutkiewicz, Emily, Gnegy, Margaret E
Publicado no Neuropsychopharmacology (2017)

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition

Por Beyett, Tyler S., Gan, Xinmin, Reilly, Shannon M., Chang, Louise, Gomez, Andrew V., Saltiel, Alan R., Showalter, Hollis D., Tesmer, John J. G.
Publicado no Mol Pharmacol (2018)

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and...

Por Beyett, Tyler S., Gan, Xinmin, Reilly, Shannon M., Gomez, Andrew V., Chang, Louise, Tesmer, John J. G., Saltiel, Alan R., Showalter, Hollis D.
Publicado no Bioorg Med Chem (2018)

Chemical Derivatives of a Small Molecule Deubiquitinase Inhibitor Have Antiviral Activity against Several RNA Viruses

Por Gonzalez-Hernandez, Marta J., Pal, Anupama, Gyan, Kofi E., Charbonneau, Marie-Eve, Showalter, Hollis D., Donato, Nicholas J., O'Riordan, Mary, Wobus, Christiane E.
Publicado em 2014

Substrate-competitive activity-based profiling of ester prodrug activating enzymes

Por Xu, Hao, Majmudar, Jaimeen D., Davda, Dahvid, Ghanakota, Phani, Kim, Ki H., Carlson, Heather A., Showalter, Hollis D., Martin, Brent R., Amidon, Gordon L.
Publicado no Mol Pharm (2015)

Lipid Storage Disorders Block Lysosomal Trafficking By Inhibiting TRP Channel and Calcium Release

Por Shen, Dongbiao, Wang, Xiang, Li, Xinran, Zhang, Xiaoli, Yao, Zepeng, Dibble, Shannon, Dong, Xian-ping, Yu, Ting, Lieberman, Andrew P., Showalter, Hollis D., Xu, Haoxing
Publicado em 2012

Use of Enterally Delivered Angiotensin II Type Ia Receptor Antagonists to Reduce the Severity of Colitis

Por Okawada, Manabu, Koga, Hiroyuki, Larsen, Scott D., Showalter, Hollis D., Turbiak, Anjanette J., Jin, Xiaohong, Lucas, Peter C., Lipka, Elke, Hillfinger, John, Kim, Jae Seung, Teitelbaum, Daniel H.
Publicado em 2011

Menin-MLL Inhibitors Reverse Oncogenic Activity of MLL Fusion Proteins in Leukemia

Por Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G., Sorenson, Roderick J., Showalter, Hollis D., Murai, Marcelo, Belcher, Amalia, Hartley, Thomas, Hess, Jay L., Cierpicki, Tomasz
Publicado em 2012

Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens

Por Passalacqua, Karla D., Charbonneau, Marie-Eve, Donato, Nicholas J., Showalter, Hollis D., Sun, Duxin, Wen, Bo, He, Miao, Sun, Hanshi, O'Riordan, Mary X. D., Wobus, Christiane E.
Publicado no Antimicrob Agents Chemother (2016)

Degrasyn-like Symmetrical Compounds: Possible Therapeutic Agents for Multiple Myeloma (MM-I)

Por Peng, Zhenghong, Maxwell, David, Sun, Duoli, Bhanu Prasad, Basvoju A., Schuber, Paul T., Pal, Ashutosh, Ying, Yunming, Han, Dongmei, Gao, Liwei, Wang, Shimei, Levitzki, Alexander, Kapuria, Vaibhav, Talpaz, Moshe, Young, Matthew, Showalter, Hollis D., Donato, Nicholas J., Bornmann, William. G.
Publicado em 2014

Complementary Cell-Based High Throughput Screens Identify Novel Modulators of the Unfolded Protein Response

Por Fribley, Andrew M., Cruz, Patricia G., Miller, Justin R., Callaghan, Michael U., Cai, Peter, Narula, Neha, Neubig, Richard R., Showalter, Hollis D., Larsen, Scott D., Kirchhoff, Paul D., Larsen, Martha J., Burr, Douglas A., Schultz, Pamela J., Jacobs, Renju R., Tamayo-Castillo, Giselle, Ron, David, Sherman, David H., Kaufman, Randal J.
Publicado em 2011