Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition

Chronic low-grade inflammation is a hallmark of obesity, which is a risk factor for the development of type 2 diabetes. The drug amlexanox inhibits IκB kinase ε (IKKε) and TANK binding kinase 1 (TBK1) to promote energy expenditure and improve insulin sensitivity. Clinical studies have demonstrated e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Pharmacol
Prif Awduron: Beyett, Tyler S., Gan, Xinmin, Reilly, Shannon M., Chang, Louise, Gomez, Andrew V., Saltiel, Alan R., Showalter, Hollis D., Tesmer, John J. G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2018
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128810/
https://ncbi.nlm.nih.gov/pubmed/30082428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112185
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