A Small Molecule Deubiquitinase Inhibitor Increases Localization of Inducible Nitric Oxide Synthase to the Macrophage Phagosome and Enhances Bacterial Killing

Macrophages are key mediators of antimicrobial defense and innate immunity. Innate intracellular defense mechanisms can be rapidly regulated at the posttranslational level by the coordinated addition and removal of ubiquitin by ubiquitin ligases and deubiquitinases (DUBs). While ubiquitin ligases ha...

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Main Authors: Burkholder, Kristin M., Perry, Jeffrey W., Wobus, Christiane E., Donato, Nicholas J., Showalter, Hollis D., Kapuria, Vaibhav, O'Riordan, Mary X. D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232648/
https://ncbi.nlm.nih.gov/pubmed/21911458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05456-11
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