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A Small Molecule Deubiquitinase Inhibitor Increases Localization of Inducible Nitric Oxide Synthase to the Macrophage Phagosome and Enhances Bacterial Killing

Macrophages are key mediators of antimicrobial defense and innate immunity. Innate intracellular defense mechanisms can be rapidly regulated at the posttranslational level by the coordinated addition and removal of ubiquitin by ubiquitin ligases and deubiquitinases (DUBs). While ubiquitin ligases ha...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Burkholder, Kristin M., Perry, Jeffrey W., Wobus, Christiane E., Donato, Nicholas J., Showalter, Hollis D., Kapuria, Vaibhav, O'Riordan, Mary X. D.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232648/
https://ncbi.nlm.nih.gov/pubmed/21911458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05456-11
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