A Small Molecule Deubiquitinase Inhibitor Increases Localization of Inducible Nitric Oxide Synthase to the Macrophage Phagosome and Enhances Bacterial Killing

Macrophages are key mediators of antimicrobial defense and innate immunity. Innate intracellular defense mechanisms can be rapidly regulated at the posttranslational level by the coordinated addition and removal of ubiquitin by ubiquitin ligases and deubiquitinases (DUBs). While ubiquitin ligases ha...

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Autors principals: Burkholder, Kristin M., Perry, Jeffrey W., Wobus, Christiane E., Donato, Nicholas J., Showalter, Hollis D., Kapuria, Vaibhav, O'Riordan, Mary X. D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Host Response and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232648/
https://ncbi.nlm.nih.gov/pubmed/21911458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05456-11
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