Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

Amphetamines (AMPHs) are globally abused. With no effective treatment for AMPH addiction to date, there is urgent need for the identification of druggable targets that mediate the reinforcing action of this stimulant class. AMPH-stimulated dopamine efflux is modulated by protein kinase C (PKC) activ...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Carpenter, Colleen, Zestos, Alexander G, Altshuler, Rachel, Sorenson, Roderick J, Guptaroy, Bipasha, Showalter, Hollis D, Kennedy, Robert T, Jutkiewicz, Emily, Gnegy, Margaret E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561350/
https://ncbi.nlm.nih.gov/pubmed/28492278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.95
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