Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases

The enzyme tRNA-guanine transglycosylase (TGT) is involved in the queuosine modification of tRNAs in eukarya and eubacteria and in the archaeosine modification of tRNAs in archaea. However, the different classes of TGTs utilize different heterocyclic substrates (and tRNA in the case of archaea). Bas...

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Detalles Bibliográficos
Main Authors: Chen, Yi-Chen, Brooks, Allen F., Goodenough-Lashua, DeeAnne M., Kittendorf, Jeffrey D., Showalter, Hollis D., Garcia, George A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074131/
https://ncbi.nlm.nih.gov/pubmed/21131277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1188
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