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Lipid Storage Disorders Block Lysosomal Trafficking By Inhibiting TRP Channel and Calcium Release
Lysosomal lipid accumulation, defects in membrane trafficking, and altered Ca(2+) homeostasis are common features in many lysosomal storage diseases. Mucolipin TRP channel 1 (TRPML1) is the principle Ca(2+) channel in the lysosome. Here we show that TRPML1-mediated lysosomal Ca(2+) release, measured...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347486/ https://ncbi.nlm.nih.gov/pubmed/22415822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1735 |
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