Lipid Storage Disorders Block Lysosomal Trafficking By Inhibiting TRP Channel and Calcium Release

Lysosomal lipid accumulation, defects in membrane trafficking, and altered Ca(2+) homeostasis are common features in many lysosomal storage diseases. Mucolipin TRP channel 1 (TRPML1) is the principle Ca(2+) channel in the lysosome. Here we show that TRPML1-mediated lysosomal Ca(2+) release, measured...

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Main Authors: Shen, Dongbiao, Wang, Xiang, Li, Xinran, Zhang, Xiaoli, Yao, Zepeng, Dibble, Shannon, Dong, Xian-ping, Yu, Ting, Lieberman, Andrew P., Showalter, Hollis D., Xu, Haoxing
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347486/
https://ncbi.nlm.nih.gov/pubmed/22415822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1735
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