The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

Por Shayman, James A., Larsen, Scott D.
Publicado em 2014

Efficient, Divergent Synthesis of Cryptophycin Unit A Analogues

Por Bolduc, Kyle L., Larsen, Scott D., Sherman, David H.
Publicado em 2012

Structural and Functional Analysis of G Protein–Coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog

Por Homan, Kristoff T., Wu, Emily, Wilson, Michael W., Singh, Puja, Larsen, Scott D., Tesmer, John J. G.
Publicado em 2014

Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation

Por Ma, Yibao, Xu, Yuanxi, Yestrepsky, Bryan D., Sorenson, Roderick J., Chen, Meng, Larsen, Scott D., Sun, Hongmin
Publicado em 2012

MScreen: An Integrated Compound Management and High Throughput Screening (HTS) Data Storage and Analysis System

Por Jacob, Renju T., Larsen, Martha J., Larsen, Scott D., Kirchhoff, Paul D., Sherman, David H., Neubig, Richard R.
Publicado em 2012

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

Por Bell, Jessica L, Haak, Andrew J, Wade, Susan M, Sun, Yihan, Neubig, Richard R, Larsen, Scott D
Publicado em 2013

Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents

Por Yestrepsky, Bryan D., Kretz, Colin A., Xu, Yuanxi, Holmes, Autumn, Sun, Hongmin, Ginsburg, David, Larsen, Scott D.
Publicado em 2014

Optimization of Novel Nipecotic Bis(amide) Inhibitors of the Rho/MKL1/SRF Transcriptional Pathway as Potential Anti-metastasis Agents

Por Bell, Jessica L., Haak, Andrew J., Wade, Susan M., Kirchhoff, Paul D., Neubig, Richard R., Larsen, Scott D.
Publicado em 2013

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

Por Johnson, Laura A., Rodansky, Eva S., Haak, Andrew J., Larsen, Scott D., Neubig, Richard R., Higgins, Peter D. R.
Publicado no Inflamm Bowel Dis (2014)

Occludin S471 Phosphorylation Contributes to Epithelial Monolayer Maturation

Por Bolinger, Mark T., Ramshekar, Aniket, Waldschmidt, Helen V., Larsen, Scott D., Bewley, Maria C., Flanagan, John M., Antonetti, David A.
Publicado no Mol Cell Biol (2016)

Identification of Thieno[3,2-b]Pyrrole Derivatives as Novel Small Molecule Inhibitors of Neurotropic Alphaviruses

Por Peng, Weiping, Peltier, Daniel C., Larsen, Martha J., Kirchhoff, Paul D., Larsen, Scott D., Neubig, Richard R., Miller, David J.
Publicado em 2009

Redox modification of nuclear actin by MICAL-2 regulates SRF signaling

Por Lundquist, Mark R., Storaska, Andrew J., Liu, Ting-Chun, Larsen, Scott D., Evans, Todd, Neubig, Richard R., Jaffrey, Samie R.
Publicado no Cell (2014)

CARP-1 functional mimetics are novel inhibitors of drug-resistant triple negative breast cancers

Por Cheriyan, Vino T., Muthu, Magesh, Patel, Ketan, Sekhar, Sreeja, Rajeswaran, Walajapet, Larsen, Scott D., Polin, Lisa, Levi, Edi, Singh, Mandip, Rishi, Arun K.
Publicado no Oncotarget (2016)

Discovery of Anthranilamides as a Novel Class of Inhibitors of Neurotropic Alphavirus Replication

Por Barraza, Scott J., Delekta, Philip C., Sindac, Janice A., Dobry, Craig J., Xiang, Jianming, Keep, Richard F., Miller, David J., Larsen, Scott D.
Publicado no Bioorg Med Chem (2015)

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor

Por Homan, Kristoff T., Waldschmidt, Helen V., Glukhova, Alisa, Cannavo, Alessandro, Song, Jianliang, Cheung, Joseph Y., Koch, Walter J., Larsen, Scott D., Tesmer, John J. G.
Publicado no J Biol Chem (2015)

Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Mod...

Por Haak, Andrew J., Tsou, Pei-Suen, Amin, Mohammad A., Ruth, Jeffrey H., Campbell, Phillip, Fox, David A., Khanna, Dinesh, Larsen, Scott D., Neubig, Richard R.
Publicado em 2014

Novel Inhibitors of Neurotropic Alphavirus Replication That Improve Host Survival in a Mouse Model of Acute Viral Encephalitis

Por Sindac, Janice, Yestrepsky, Bryan D., Barraza, Scott J., Bolduc, Kyle L., Blakely, Pennelope K., Keep, Richard F., Irani, David N., Miller, David J., Larsen, Scott D.
Publicado em 2012

Small Molecule Screening Identifies Regulators of the Transcription Factor ΔFosB

Por Wang, Yun, Cesena, Teresa I., Ohnishi, Yoko, Burger-Caplan, Rebecca, Lam, Vivian, Kirchhoff, Paul D., Larsen, Scott D., Larsen, Martha J., Nestler, Eric J., Rudenko, Gabby
Publicado em 2012

Optimization of Novel Indole-2-carboxamide Inhibitors of Neurotropic Alphavirus Replication

Por Sindac, Janice A., Barraza, Scott J., Dobry, Craig J., Xiang, Jianming, Blakely, Pennelope K., Irani, David N., Keep, Richard F., Miller, David J., Larsen, Scott D.
Publicado em 2013

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

Por Evelyn, Chris R., Bell, Jessica L., Ryu, Jenny G., Wade, Susan M., Kocab, Andrew, Harzdorf, Nicole L., Showalter, H. D. Hollis, Neubig, Richard R., Larsen, Scott D.
Publicado em 2009