Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

CCG-1423 and related analogues represent a new class of inhibitors of Rho/MKL1/SRF-mediated gene transcription, a pathway that has been implicated in both cancer and fibrosis. The molecular target for these compounds is unknown. To facilitate its identification, a series of tag-free photoaffinity pr...

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Hlavní autoři: Bell, Jessica L, Haak, Andrew J, Wade, Susan M, Sun, Yihan, Neubig, Richard R, Larsen, Scott D
Médium: Artigo
Jazyk:Inglês
Vydáno: Beilstein-Institut 2013
Témata:
Letter
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678708/
https://ncbi.nlm.nih.gov/pubmed/23766813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.111
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