Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks

Metastasis is the major cause of cancer deaths and control of gene transcription has emerged as a critical contributing factor. RhoA- and RhoC-induced gene transcription via the actin-regulated transcriptional co-activator megakaryocytic leukemia (MKL) and serum response factor (SRF) drive metastasi...

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Detalhes bibliográficos
Publicado no:Microarrays (Basel)
Main Authors: Evelyn, Chris R., Lisabeth, Erika M., Wade, Susan M., Haak, Andrew J., Johnson, Craig N., Lawlor, Elizabeth R., Neubig, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003489/
https://ncbi.nlm.nih.gov/pubmed/27600078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microarrays5020013
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