Matrix Biomechanics and Dynamics in Pulmonary Fibrosis

por Haak, Andrew J., Tan, Qi, Tschumperlin, Daniel J.
Publicado no Matrix Biol (2017)

Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription

por Tsou, Pei-Suen, Haak, Andrew J., Khanna, Dinesh, Neubig, Richard R.
Publicado em 2014

Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies

por Haak, Andrew J., Ducharme, Merrick T., Espinosa, Ana M. Diaz, Tschumperlin, Daniel J.
Publicado no Trends Pharmacol Sci (2020)

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

por Bell, Jessica L, Haak, Andrew J, Wade, Susan M, Sun, Yihan, Neubig, Richard R, Larsen, Scott D
Publicado em 2013

Aging and anatomical variations in lung tissue stiffness

por Sicard, Delphine, Haak, Andrew J., Choi, Kyoung Moo, Craig, Alexandria R., Fredenburgh, Laura E., Tschumperlin, Daniel J.
Publicado no Am J Physiol Lung Cell Mol Physiol (2018)

Dopamine D1 receptor stimulates cathepsin K-dependent degradation and resorption of collagen I in lung fibroblasts

por Diaz Espinosa, Ana M., Link, Patrick A., Sicard, Delphine, Jorba, Ignasi, Tschumperlin, Daniel J., Haak, Andrew J.
Publicado no J Cell Sci (2020)

Optimization of Novel Nipecotic Bis(amide) Inhibitors of the Rho/MKL1/SRF Transcriptional Pathway as Potential Anti-metastasis Agents

por Bell, Jessica L., Haak, Andrew J., Wade, Susan M., Kirchhoff, Paul D., Neubig, Richard R., Larsen, Scott D.
Publicado em 2013

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

por Johnson, Laura A., Rodansky, Eva S., Haak, Andrew J., Larsen, Scott D., Neubig, Richard R., Higgins, Peter D. R.
Publicado no Inflamm Bowel Dis (2014)

Phenylpyrrolidine structural mimics of pirfenidone lacking antifibrotic activity: a new tool for mechanism of action studies

por Haak, Andrew J., Girtman, Megan A., Ali, Mohamed F., Carmona, Eva M., Limper, Andrew H., Tschumperlin, Daniel J.
Publicado no Eur J Pharmacol (2017)

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks

por Evelyn, Chris R., Lisabeth, Erika M., Wade, Susan M., Haak, Andrew J., Johnson, Craig N., Lawlor, Elizabeth R., Neubig, Richard R.
Publicado no Microarrays (Basel) (2016)

Nascent Lung Organoids Reveal Epithelium- and Bone Morphogenetic Protein–mediated Suppression of Fibroblast Activation

por Tan, Qi, Ma, Xiao Yin, Liu, Wei, Meridew, Jeffrey A., Jones, Dakota L., Haak, Andrew J., Sicard, Delphine, Ligresti, Giovanni, Tschumperlin, Daniel J.
Publicado no Am J Respir Cell Mol Biol (2019)

TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation

por Aravamudhan, Aja, Haak, Andrew J., Choi, Kyoung Moo, Meridew, Jeffrey A., Caporarello, Nunzia, Jones, Dakota L., Tan, Qi, Ligresti, Giovanni, Tschumperlin, Daniel J.
Publicado no Am J Physiol Lung Cell Mol Physiol (2020)

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

por Jones, Dakota L., Haak, Andrew J., Caporarello, Nunzia, Choi, Kyoung M., Ye, Zhenqing, Yan, Huihuang, Varelas, Xaralabos, Ordog, Tamas, Ligresti, Giovanni, Tschumperlin, Daniel J.
Publicado no J Cell Sci (2019)

Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Mod...

por Haak, Andrew J., Tsou, Pei-Suen, Amin, Mohammad A., Ruth, Jeffrey H., Campbell, Phillip, Fox, David A., Khanna, Dinesh, Larsen, Scott D., Neubig, Richard R.
Publicado em 2014

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

por Caporarello, Nunzia, Meridew, Jeffrey A, Jones, Dakota L, Tan, Qi, Haak, Andrew J, Choi, Kyoung M, Manlove, Logan J, Prakash, Y S, Tschumperlin, Daniel J, Ligresti, Giovanni
Publicado no Thorax (2019)

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis

por Ligresti, Giovanni, Caporarello, Nunzia, Meridew, Jeffrey A., Jones, Dakota L., Tan, Qi, Choi, Kyoung Moo, Haak, Andrew J., Aravamudhan, Aja, Roden, Anja C., Prakash, Y.S., Lomberk, Gwen, Urrutia, Raul A., Tschumperlin, Daniel J.
Publicado no JCI Insight (2019)

Vascular dysfunction in aged mice contributes to persistent lung fibrosis

por Caporarello, Nunzia, Meridew, Jeffrey A., Aravamudhan, Aja, Jones, Dakota L., Austin, Susan A., Pham, Tho X., Haak, Andrew J., Moo Choi, Kyoung, Tan, Qi, Haresi, Adil, Huang, Steven K., Katusic, Zvonimir S., Tschumperlin, Daniel J., Ligresti, Giovanni
Publicado no Aging Cell (2020)

Pharmacological inhibition of Myocardin-related transcription factor pathway blocks lung metastases of RhoC overexpressing melanoma

por Haak, Andrew J., Appleton, Kathryn M., Lisabeth, Erika M., Misek, Sean, Ji, Yajing, Wade, Susan M., Bell, Jessica L., Rockwell, Cheryl E., Airik, Merlin, Krook, Melanie A., Larsen, Scott D., Verhaegen, Monique, Lawlor, Elizabeth R., Neubig, Richard R.
Publicado no Mol Cancer Ther (2016)

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Reponse Factor (SRF)-Mediated Gene...

por Kahl, Dylan J., Hutchings, Kim M., Lisabeth, Erika Mathes, Haak, Andrew J., Leipprandt, Jeffrey R., Dexheimer, Thomas, Khanna, Dinesh, Tsou, Pei-Suen, Campbell, Phillip L., Fox, David A., Wen, Bo, Sun, Duxin, Bailie, Marc, Neubig, Richard R., Larsen, Scott D.
Publicado no J Med Chem (2019)

RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation

por Oh, Raymond S., Haak, Andrew J., Smith, Karry M. J., Ligresti, Giovanni, Choi, Kyoung Moo, Xie, Tiao, Wang, Shaohua, Walters, Paula R., Thompson, Michael A., Freeman, Michelle R., Manlove, Logan J., Chu, Vivian M., Feghali-Bostwick, Carol, Roden, Anja C., Schymeinsky, Jürgen, Pabelick, Christina M., Prakash, Y. S., Vassallo, Robert, Tschumperlin, Daniel J.
Publicado no J Cell Sci (2018)