Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription

Por Tsou, Pei-Suen, Haak, Andrew J., Khanna, Dinesh, Neubig, Richard R.
Publicado em 2014

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

Por Bell, Jessica L, Haak, Andrew J, Wade, Susan M, Sun, Yihan, Neubig, Richard R, Larsen, Scott D
Publicado em 2013

Optimization of Novel Nipecotic Bis(amide) Inhibitors of the Rho/MKL1/SRF Transcriptional Pathway as Potential Anti-metastasis Agents

Por Bell, Jessica L., Haak, Andrew J., Wade, Susan M., Kirchhoff, Paul D., Neubig, Richard R., Larsen, Scott D.
Publicado em 2013

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

Por Johnson, Laura A., Rodansky, Eva S., Haak, Andrew J., Larsen, Scott D., Neubig, Richard R., Higgins, Peter D. R.
Publicado no Inflamm Bowel Dis (2014)

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks

Por Evelyn, Chris R., Lisabeth, Erika M., Wade, Susan M., Haak, Andrew J., Johnson, Craig N., Lawlor, Elizabeth R., Neubig, Richard R.
Publicado no Microarrays (Basel) (2016)

Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Mod...

Por Haak, Andrew J., Tsou, Pei-Suen, Amin, Mohammad A., Ruth, Jeffrey H., Campbell, Phillip, Fox, David A., Khanna, Dinesh, Larsen, Scott D., Neubig, Richard R.
Publicado em 2014

Cellular senescence mediates fibrotic pulmonary disease

Por Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.
Publicado no Nat Commun (2017)