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TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression
Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently been linked to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhibiting or reversing TGFβ-mediated fibroblast activ...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6826010/ https://ncbi.nlm.nih.gov/pubmed/31527052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.233486 |
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