PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

Idiopathic pulmonary fibrosis (IPF) is a fatal ageing-related disease linked to mitochondrial dysfunction. The present study aimed to determine whether peroxisome proliferator activated receptor gamma co-activator 1-alpha (PPARGC1A, encoding PGC1α), a master regulator of mitochondrial biogenesis, is...

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Bibliografiske detaljer
Udgivet i:Thorax
Main Authors: Caporarello, Nunzia, Meridew, Jeffrey A, Jones, Dakota L, Tan, Qi, Haak, Andrew J, Choi, Kyoung M, Manlove, Logan J, Prakash, Y S, Tschumperlin, Daniel J, Ligresti, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2019
Fag:
Interstitial Lung Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703129/
https://ncbi.nlm.nih.gov/pubmed/31182654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213064
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