CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis

Pulmonary fibrosis is a devastating disease characterized by accumulation of activated fibroblasts and scarring in the lung. While fibroblast activation in physiological wound repair reverses spontaneously, fibroblast activation in fibrosis is aberrantly sustained. Here we identified histone 3 lysin...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Ligresti, Giovanni, Caporarello, Nunzia, Meridew, Jeffrey A., Jones, Dakota L., Tan, Qi, Choi, Kyoung Moo, Haak, Andrew J., Aravamudhan, Aja, Roden, Anja C., Prakash, Y.S., Lomberk, Gwen, Urrutia, Raul A., Tschumperlin, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629126/
https://ncbi.nlm.nih.gov/pubmed/31095524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127111
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