PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

Idiopathic pulmonary fibrosis (IPF) is a fatal ageing-related disease linked to mitochondrial dysfunction. The present study aimed to determine whether peroxisome proliferator activated receptor gamma co-activator 1-alpha (PPARGC1A, encoding PGC1α), a master regulator of mitochondrial biogenesis, is...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Caporarello, Nunzia, Meridew, Jeffrey A, Jones, Dakota L, Tan, Qi, Haak, Andrew J, Choi, Kyoung M, Manlove, Logan J, Prakash, Y S, Tschumperlin, Daniel J, Ligresti, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Interstitial Lung Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703129/
https://ncbi.nlm.nih.gov/pubmed/31182654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213064
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados