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Dopamine D1 receptor stimulates cathepsin K-dependent degradation and resorption of collagen I in lung fibroblasts

Matrix resorption is essential to the clearance of the extracellular matrix (ECM) after normal wound healing. A disruption in these processes constitutes a main component of fibrotic diseases, characterized by excess deposition and diminished clearance of fibrillar ECM proteins, such as collagen typ...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Diaz Espinosa, Ana M., Link, Patrick A., Sicard, Delphine, Jorba, Ignasi, Tschumperlin, Daniel J., Haak, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746663/
https://ncbi.nlm.nih.gov/pubmed/33172983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.248278
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