Cathepsin K Is a Critical Protease in Synovial Fibroblast-Mediated Collagen Degradation

Synovial fibroblasts (SFs) play a critical role in the pathogenesis of rheumatoid arthritis (RA) and are directly involved in joint destruction. Both SF-resident matrix metalloproteases and cathepsins have been implicated in cartilage degradation although their identities and individual contribution...

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Detalhes bibliográficos
Main Authors: Hou, Wu-Shiun, Li, Zhenqiang, Gordon, Ronald E., Chan, Kyle, Klein, Michael J., Levy, Roger, Keysser, Martin, Keyszer, Gernot, Brömme, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2001
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850593/
https://ncbi.nlm.nih.gov/pubmed/11733367
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