Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationship study focusing on bioisosteric replacement of t...

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Hlavní autoři: Evelyn, Chris R., Bell, Jessica L., Ryu, Jenny G., Wade, Susan M., Kocab, Andrew, Harzdorf, Nicole L., Showalter, H. D. Hollis, Neubig, Richard R., Larsen, Scott D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818594/
https://ncbi.nlm.nih.gov/pubmed/19963382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.056
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