The XIAP IRES activates 3′ cistron expression by inducing production of monocistronic mRNA in the βgal/CAT bicistronic reporter system

par Saffran, Holly A., Smiley, James R.
Publié 2009

The vhs1 Mutant Form of Herpes Simplex Virus Virion Host Shutoff Protein Retains Significant Internal Ribosome Entry Site-Directed RNA Cleavage Activity

par Lu, Patricia, Saffran, Holly A., Smiley, James R.
Publié 2001

The Herpes Simplex Virus 1 Virion Host Shutoff Protein Enhances Translation of Viral Late mRNAs by Preventing mRNA Overload

par Dauber, Bianca, Saffran, Holly A., Smiley, James R.
Publié 2014

The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA

par Dauber, Bianca, Saffran, Holly A., Smiley, James R.
Publié dans PLoS Pathog (2019)

Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon

par Mossman, Karen L., Saffran, Holly A., Smiley, James R.
Publié 2000

RNA Degradation Induced by the Herpes Simplex Virus vhs Protein Proceeds 5′ to 3′ In Vitro

par Perez-Parada, Jorge, Saffran, Holly A., Smiley, James R.
Publié 2004

Herpes Simplex Virus Infection Stabilizes Cellular IEX-1 mRNA

par Hsu, Wei-Li, Saffran, Holly A., Smiley, James R.
Publié 2005

Evidence for Translational Regulation by the Herpes Simplex Virus Virion Host Shutoff Protein

par Saffran, Holly A., Read, G. Sullivan, Smiley, James R.
Publié 2010

Herpes Simplex Virus Virion Host Shutoff Protein Requires a Mammalian Factor for Efficient In Vitro Endoribonuclease Activity

par Lu, Patricia, Jones, Frank E., Saffran, Holly A., Smiley, James R.
Publié 2001

Role of Herpes Simplex Virus VP11/12 Tyrosine-Based Motifs in Binding and Activation of the Src Family Kinase Lck and Recruitment of p85, Grb2, and Shc

par Strunk, Ulrike, Saffran, Holly A., Wu, Frederick W., Smiley, James R.
Publié 2013

Herpes Simplex Virus Virion Host Shutoff Protein Is Stimulated by Translation Initiation Factors eIF4B and eIF4H

par Doepker, Rosalyn C., Hsu, Wei-Li, Saffran, Holly A., Smiley, James R.
Publié 2004

Herpes Simplex Virus UL12.5 Targets Mitochondria through a Mitochondrial Localization Sequence Proximal to the N Terminus

par Corcoran, Jennifer A., Saffran, Holly A., Duguay, Brett A., Smiley, James R.
Publié 2009

Herpes Simplex Virus Protein Kinases US3 and UL13 Modulate VP11/12 Phosphorylation, Virion Packaging, and Phosphatidylinositol 3-Kinase/Akt Signaling Activity

par Eaton, Heather E., Saffran, Holly A., Wu, Frederick W., Quach, Kevin, Smiley, James R.
Publié 2014

Herpes simplex virus eliminates host mitochondrial DNA

par Saffran, Holly A, Pare, Justin M, Corcoran, Jennifer A, Weller, Sandra K, Smiley, James R
Publié 2007

Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication

par Duguay, Brett A., Saffran, Holly A., Ponomarev, Alina, Duley, Shayla A., Eaton, Heather E., Smiley, James R.
Publié 2014

The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation

par Dauber, Bianca, Poon, David, dos Santos, Theodore, Duguay, Brett A., Mehta, Ninad, Saffran, Holly A., Smiley, James R.
Publié dans J Virol (2016)

Expression of the Vaccinia Virus Antiapoptotic F1 Protein Is Blocked by Protein Kinase R in the Absence of the Viral E3 Protein

par Mehta, Ninad, Enwere, Emeka K., Santos, Theodore Dos, Saffran, Holly A., Hazes, Bart, Evans, David, Barry, Michele, Smiley, James R.
Publié dans J Virol (2018)

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

par Vuong, Wayne, Khan, Muhammad Bashir, Fischer, Conrad, Arutyunova, Elena, Lamer, Tess, Shields, Justin, Saffran, Holly A., McKay, Ryan T., van Belkum, Marco J., Joyce, Michael A., Young, Howard S., Tyrrell, D. Lorne, Vederas, John C., Lemieux, M. Joanne
Publié dans Nat Commun (2020)

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

par Vuong, Wayne, Khan, Muhammad Bashir, Fischer, Conrad, Arutyunova, Elena, Lamer, Tess, Shields, Justin, Saffran, Holly A., McKay, Ryan T., van Belkum, Marco J., Joyce, Michael A., Young, Howard S., Tyrrell, D. Lorne, Vederas, John C., Lemieux, M. Joanne
Publié dans Nat Commun (2020)

Improved SARS-CoV-2 M(pro) inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

par Vuong, Wayne, Fischer, Conrad, Khan, Muhammad Bashir, van Belkum, Marco J., Lamer, Tess, Willoughby, Kurtis D., Lu, Jimmy, Arutyunova, Elena, Joyce, Michael A., Saffran, Holly A., Shields, Justin A., Young, Howard S., Nieman, James A., Tyrrell, D. Lorne, Lemieux, M. Joanne, Vederas, John C.
Publié dans Eur J Med Chem (2021)