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Herpes Simplex Virus UL12.5 Targets Mitochondria through a Mitochondrial Localization Sequence Proximal to the N Terminus

The herpes simplex virus type 1 (HSV-1) gene UL12 encodes a conserved alkaline DNase with orthologues in all herpesviruses. The HSV-1 UL12 gene gives rise to two separately promoted 3′ coterminal mRNAs which encode distinct but related proteins: full-length UL12 and UL12.5, an amino-terminally trunc...

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Bibliographic Details
Main Authors: Corcoran, Jennifer A., Saffran, Holly A., Duguay, Brett A., Smiley, James R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648271/
https://ncbi.nlm.nih.gov/pubmed/19129438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02087-08
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