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Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication

Infection with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host cells. It is known that a mitochondrial isoform of the viral alkaline nuclease (UL12) called UL12.5 triggers this process. However, very little is known about the impact of mtDN...

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Detalhes bibliográficos
Main Authors: Duguay, Brett A., Saffran, Holly A., Ponomarev, Alina, Duley, Shayla A., Eaton, Heather E., Smiley, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958086/
https://ncbi.nlm.nih.gov/pubmed/24371054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03129-13
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