The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA

The herpes simplex virus virion host shutoff (vhs) RNase destabilizes cellular and viral mRNAs and blunts host innate antiviral responses. Previous work demonstrated that cells infected with vhs mutants display enhanced activation of the host double-stranded RNA (dsRNA)-activated protein kinase R (P...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Dauber, Bianca, Saffran, Holly A., Smiley, James R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821131/
https://ncbi.nlm.nih.gov/pubmed/31626661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008111
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