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The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation

The herpes simplex virus (HSV) virion host shutoff (vhs) RNase destabilizes cellular and viral mRNAs, suppresses host protein synthesis, dampens antiviral responses, and stimulates translation of viral mRNAs. vhs mutants display a host range phenotype: translation of viral true late mRNAs is severel...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Dauber, Bianca, Poon, David, dos Santos, Theodore, Duguay, Brett A., Mehta, Ninad, Saffran, Holly A., Smiley, James R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907241/
https://ncbi.nlm.nih.gov/pubmed/27099317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03180-15
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