The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation

The herpes simplex virus (HSV) virion host shutoff (vhs) RNase destabilizes cellular and viral mRNAs, suppresses host protein synthesis, dampens antiviral responses, and stimulates translation of viral mRNAs. vhs mutants display a host range phenotype: translation of viral true late mRNAs is severel...

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Vydáno v:J Virol
Hlavní autoři: Dauber, Bianca, Poon, David, dos Santos, Theodore, Duguay, Brett A., Mehta, Ninad, Saffran, Holly A., Smiley, James R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907241/
https://ncbi.nlm.nih.gov/pubmed/27099317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03180-15
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