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Role of Herpes Simplex Virus VP11/12 Tyrosine-Based Motifs in Binding and Activation of the Src Family Kinase Lck and Recruitment of p85, Grb2, and Shc

Previous studies have shown that the abundant herpes simplex virus 1 (HSV-1) tegument protein VP11/12, encoded by gene UL46, stimulates phosphatidylinositol 3-kinase (PI3-kinase)/Akt signaling: it binds the Src family kinase (SFK) Lck, is tyrosine phosphorylated, recruits the p85 subunit of PI3-kina...

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Detalhes bibliográficos
Main Authors: Strunk, Ulrike, Saffran, Holly A., Wu, Frederick W., Smiley, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807303/
https://ncbi.nlm.nih.gov/pubmed/23946459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01702-13
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