Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

The main protease, M(pro) (or 3CL(pro)) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously with a prodrug GC376, a dipeptide-based prot...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Vuong, Wayne, Khan, Muhammad Bashir, Fischer, Conrad, Arutyunova, Elena, Lamer, Tess, Shields, Justin, Saffran, Holly A., McKay, Ryan T., van Belkum, Marco J., Joyce, Michael A., Young, Howard S., Tyrrell, D. Lorne, Vederas, John C., Lemieux, M. Joanne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453019/
https://ncbi.nlm.nih.gov/pubmed/32855413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18096-2
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