N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 M(pro) Dimer

The main protease (M(pro), also known as 3CL protease) of SARS-CoV-2 is a high priority drug target in the development of antivirals to combat COVID-19 infections. A feline coronavirus antiviral drug, GC376, has been shown to be effective in inhibiting the SARS-CoV-2 main protease and live virus gro...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Arutyunova, Elena, Khan, Muhammad Bashir, Fischer, Conrad, Lu, Jimmy, Lamer, Tess, Vuong, Wayne, van Belkum, Marco J., McKay, Ryan T., Tyrrell, D. Lorne, Vederas, John C., Young, Howard S., Lemieux, M. Joanne
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8061786/
https://ncbi.nlm.nih.gov/pubmed/33895266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.167003
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