Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs

von McGrath, Megan, Raines, Douglas E.
Veröffentlicht in Methods Enzymol (2018)

The Kinetics of Anesthetic-induced Conformational Transitions in a Four-α-Helix Bundle Protein

von Solt, Ken, Johansson, Jonas S., Raines, Douglas E.
Veröffentlicht 2006

The Pyrrole Etomidate Analog Carboetomidate Potently Inhibits Human 5-HT(3A) Receptor Function: Comparisons with Etomidate and Potential Implications for Emetogenesis

von Desai, Rooma, Miller, Keith W., Raines, Douglas E.
Veröffentlicht 2013

Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis

von McGrath, Megan, Ma, Celena, Raines, Douglas E.
Veröffentlicht in J Pharmacol Exp Ther (2018)

Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats

von McGrath, Megan, Hofmann, Alissa, Raines, Douglas E.
Veröffentlicht in BMC Pharmacol Toxicol (2019)

The Effects of a Competitive Antagonist on GABA-evoked Currents in the Presence of Sedative-Hypnotic Agents

von McGrath, Megan, Tolia, Mansi, Raines, Douglas E.
Veröffentlicht in Pharmacol Rep (2020)

Modifying Methoxycarbonyl Etomidate’s Inter-Ester Spacer Optimizes In Vitro Metabolic Stability and In Vivo Hypnotic Potency and Duration of Action

von Husain, S. Shaukat, Pejo, Ervin, Ge, Rile, Raines, Douglas E.
Veröffentlicht 2012

Anesthetic drug development: Novel drugs and new approaches

von Chitilian, Hovig V., Eckenhoff, Roderic G., Raines, Douglas E.
Veröffentlicht 2013

Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite

von Pejo, Ervin, Liu, Jifeng, Lin, Xiangjie, Raines, Douglas E.
Veröffentlicht in Anesth Analg (2016)

Sedative-Hypnotic Binding to 11β-Hydroxylase

von Pejo, Ervin, Zhou, Xiaojuan, Husain, S. Shaukat, Raines, Douglas E.
Veröffentlicht in Anesthesiology (2016)

Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate

von Ge, Rile, Pejo, Ervin, Cotten, Joseph F, Raines, Douglas E
Veröffentlicht 2013

Carboetomidate Inhibits Alpha4/Beta2 Neuronal Nicotinic Acetylcholine Receptors at Concentrations Affecting Animals

von Pierce, David W., Pejo, Ervin, Raines, Douglas E., Forman, Stuart A.
Veröffentlicht 2012

Inhibition of Human α(4)β(2) Neuronal Nicotinic Acetylcholine Receptors by Volatile Aromatic Anesthetics Depends on Drug Hydrophobicity

von Solt, Ken, Kelly, Elizabeth W., Cotten, Joseph F., Raines, Douglas E.
Veröffentlicht 2009

Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital

von Rüsch, Dirk, Braun, Hans A., Wulf, Hinnerk, Schuster, Anika, Raines, Douglas E.
Veröffentlicht 2007

Electroencephalographic and Hypnotic Recoveries Following Brief and Prolonged Infusions of Etomidate and Optimized Soft Etomidate Analogs

von Ge, Rile, Pejo, Ervin, Husain, S. Shaukat, Cotten, Joseph F., Raines, Douglas E.
Veröffentlicht 2012

Advancing Novel Anesthetics: Pharmacodynamic and Pharmacokinetic Studies of Cyclopropyl-Methoxycarbonyl Metomidate in Dogs

von Campagna, Jason A., Pojasek, Kevin, Grayzel, David, Randle, John, Raines, Douglas E.
Veröffentlicht in Anesthesiology (2014)

Molecular Properties Important for Inhaled Anesthetic Action on Human 5-HT(3A) Receptors

von Stevens, Renna J. N., Rüsch, Dirk, Davies, Paul A., Raines, Douglas E.
Veröffentlicht in Anesth Analg (2005)

Modulation of Human 5-Hydroxytryptamine Type 3AB Receptors by Volatile Anesthetics and n-Alcohols

von Stevens, Renna, Rüsch, Dirk, Solt, Ken, Raines, Douglas E., Davies, Paul A.
Veröffentlicht in J Pharmacol Exp Ther (2005)

Analogues of Etomidate: Modifications Around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

von Pejo, Ervin, Santer, Peter, Jeffrey, Spencer, Gallin, Hilary, Husain, S. Shaukat, Raines, Douglas E.
Veröffentlicht 2014

GABA(A) Receptor Modulation by Etomidate Analogues

von Pejo, Ervin, Santer, Peter, Wang, Lei, Dershwitz, Philip, Husain, S. Shaukat, Raines, Douglas E.
Veröffentlicht in Anesthesiology (2016)